GEN’s Top Articles on HIV Research
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Monday, December 1, 2025 

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World AIDS Day, first observed on December 1, 1988, is an international day to raise awareness of the global HIV/AIDS pandemic. Since its inception, the website notes, communities have stood together to show strength and solidarity against HIV stigma and to remember lives lost. 

 

As of 2024, over 40 million people in the world are diagnosed with human immunodeficiency virus (HIV)—a chronic, life-threatening infection that remains one of the leading global causes of death. Today, we take a moment to reflect on the progress made in the global fight against HIV, while recognizing the challenges that remain. This year, GEN is marking the day by highlighting a selection of our most recent and most widely read stories on HIV—articles that capture the latest developments in basic research, vaccine development, and drug discovery.

HIV Integrase Captured by Cryo-EM in Two Structural States

Cryo-EM revealed HIV-1 integrase’s distinct structures as it shifts between its two roles of DNA integration and RNA-binding. This structural plasticity offers new avenues for more effective antiviral drug development. + MORE

 

 

Monthly Oral HIV PrEP Candidate MK-8527 Progresses to Phase III

Merck’s MK-8527, a once-monthly oral PrEP candidate, advances from preclinical trials to Phase III. The candidate could improve adherence, reduce stigma, and expand prevention access. + MORE

 

 

Early Gene Therapy Provides Lasting HIV Protection in Newborn Primates

Delivering a single injection of AAV gene therapy within the first month of life protected infant primates from HIV-like infection for years. The work points to a critical early-life “window of opportunity” that could transform pediatric HIV prevention. + MORE

 

 

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HIV Vaccine Efforts Strengthened with Advanced AI at Scripps

Scripps Research will use high-performance AI computing to rapidly analyze HIV vaccine data, identify promising antibodies, and speed development of vaccines by overcoming data bottlenecks in clinical research. + MORE

 

 

HIV Tat Undermines Cellular Defenses, Enabling TB Infection

HIV’s Tat protein blocks clathrin-mediated endocytosis and autophagy, allowing Mycobacterium tuberculosis to persist and multiply inside macrophages and zebrafish models. + MORE

 

 

Nanozyme-Powered TB Test Enhances Detection for HIV Co-Infection

A bioinspired diagnostic tool developed at Tulane University improves tuberculosis detection in people with HIV by using nanozyme chemistry to drive a self-powered chip—offering same-day results without electricity or lab infrastructure. + MORE

 

 

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Explore MoA Reflective In Vitro Potency Testing for GLP-1R Agonists   

See how a mechanism-of-action reporter assay can be applied to support ICH Q2(R2) validation, paving the way for GMP lot release and stability testing of GLP-1R.  + MORE 

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UPCOMING WEBINAR

Long-Read Whole Genome Sequencing: Enhancing Diagnostic Power Across Clinical Applications

In Tuesday's GEN webinar, experts from Sampled and Rady Children’s Hospital will discuss the validation and clinical integration of PacBio HiFi long-read whole genome sequencing (WGS) as a next-generation diagnostic tool. + MORE

 

 

Scaling Cell Therapy Development from Research to Commercialization

In this GEN webinar, Nik Ekman will discuss critical considerations for scaling cell therapy processes from research through commercialization. + MORE

 

 

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